This book is a journey taking the reader from the medieval university to the contemporary campus, demonstrating how universities have continuously been challenged to respond to major societal shifts. However, the current AI revolution is different. AI is not merely a tool; it is transforming the very conditions under which knowledge is created, evaluated, and trusted. In doing so, it places the university’s traditional role as gatekeeper under increasing existential pressure. The authors provide a clear analysis of AI as a system technology and discuss its implications for scientific integrity, the transformation of academia, and the future of work at large. At the same time, they pose a fundamental question: how will AI-technologies shape our conception of of humankind and how does this inflict the university as a space for reflection and critical inquiry? This book is a powerful plea for a university that strives not only to be faster and more efficient, but above all wiser, more careful, and more humane.